Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases.

Sci Rep · 2017 · PMC5320491 · PMID 28225026

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highly significantno p-value reported

Inclusion of the F2R-related expression probe together with the 350 probes with FDR < 0.10 in the sex-stratified analysis described above reveals a highly significant female specificity of the effect of smoking on this gene.

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a clear trendno p-value reported

Thus, the median rank value of the 92 CpG sites of Table 4 was 3,048 (out of a total of 410,987 sites examined; top 0.7%) in females and 195,213 in males in NSHDS, and 9,098 (top 2%) and 218,704, respectively, in EPIC Italy, thus demonstrating a clear trend of higher female sensitivity in both cohorts.

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