Attenuated secretion of glucose-dependent insulinotropic polypeptide (GIP) does not alleviate hyperphagic obesity and insulin resistance in <i>ob/ob</i> mice.

Mol Metab · 2017 · PMC5324019 · PMID 28271035

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did not reach statistical significanceP = 0.08so close (0.05 < p ≤ 0.1)

The AUC-insulin tended to be lower in Lep ob/ob /GIP gfp/gfp mice than in Lep ob/ob /GIP +/+ , but it did not reach statistical significance (P = 0.08); insulin levels in Lep ob/ob /GIP gfp/gfp and Lep ob/ob /GIP +/+ mice were markedly elevated compared to levels in Lep ob/+ /GIP +/+ mice (AUC-insulin: 43-fold, 89-fold increase, respectively).

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