The histological analysis of the transplanted aortic segment revealed a significant reduction in plaque size in Cx3cr1 -/- Apoe -/- aortic segments in Apoe -/- recipients, whereas a trend towards reduced plaque burden was observed in Apoe -/- aortic segments transplanted into cx3cr1 -/- Apoe -/- mice did not reach statistical significance, compared to control Apoe -/- aortic segments in Apoe -/- mice ( Fig 1 ).
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Role of the CX3C chemokine receptor CX3CR1 in the pathogenesis of atherosclerosis after aortic transplantation.
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