Activation Strain Analysis of S<sub>N</sub>2 Reactions at C, N, O, and F Centers.

J Phys Chem A · 2017 · PMC5330660 · PMID 28045531

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closest p

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a strong trendno p-value reported

In particular, there is a strong trend of increasing electronegativity from C to F which goes with a more negatively charged electrophilic central atom.

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