The Ca²⁺ sensitizer CK-2066260 increases myofibrillar Ca²⁺ sensitivity and submaximal force selectively in fast skeletal muscle.

During submaximal contractions, [Ca 2+ ] i tended to decrease (∼10%) in fibres treated with 5 and 10 μ m CK‐2066260, but the decrease did not reach statistical significance ( P = 0.09); at 31°C 10 μ m CK‐2066260 had no effect on [Ca 2+ ] i during contractions (Fig. 6 B ).

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