Immune Modulation by Androgen Deprivation and Radiation Therapy: Implications for Prostate Cancer Immunotherapy.

A randomized, double-blind phase III clinical trial comparing ipilimumab monotherapy (n = 399) to placebo (n = 400) in mCRPC patients having undergone a single fraction of RT (8 Gy) and prior docetaxel did not reach statistical significance with its primary endpoint of overall survival, but found that ipilimumab was associated with reductions in PSA and slight improvements in PFS (median 4.0 months vs. 3.1 months PFS) [ 156 ].

also in 111,027 other papers