Decline in infection-related morbidities following drug-mediated reductions in the intensity of Schistosoma infection: A systematic review and meta-analysis.

Of note, the reductions in morbidities associated with urogenital schistosomiasis, with the exception of injuries to the upper urinary tract, were more likely to be significant if evaluated in the first six months after treatment.

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Studies that combined treatment for schistosomiasis with another anthelmintic (mebendazole or albendazole) and studies using capillary blood for diagnosis found higher mean differences post-treatment, but these also did not reach statistical significance (Table K in S3 Text ).

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The reduction in prevalence was highly significant after chemotherapy for S . haematobium when pooled across all studies (OR 0.08, CI 95% 0.05, 0.12).

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