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Pulmonary hypertension attenuates the dynamic preload indicators increase during experimental hypovolemia.

BMC Anesthesiol · 2017 · PMC5335759 · PMID 28253850

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Although the reduction of RV stroke work during PE did not reach statistical significance because of the concomitant increase of RV systolic pressure, the volume load did not reverse the ventricular performance, supporting the impairment of systolic function.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.