High expression of intratumoral stromal proteins is associated with chemotherapy resistance in breast cancer.

An increasing trend was observed in TNC expression in patients with pathologically involved lymph nodes (change 8.33% for cycle 1 vs baseline; change 25% for cycle 4 vs baseline) although the difference was not statistically significant (Figure 3F ).

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While high baseline α-SMA expression only showed a trend in association with both shorter PFS and OS (Figure 2C, 2F ), high α-SMA in post-treatment tumors following 1 cycle of chemotherapy was significantly associated with both shorter PFS (mean PFS 29.0 [95% CI 14.3–43.7] vs 52.4 [95% CI 42.9-63.0] months for high vs low α-SMA, p = 0.033, Figure 2D ) and OS (mean OS 43.0 [95% CI 27.2–58.7] vs 67.5 [95% CI 52.9–75.8] months for high vs low α-SMA, p = 0.012, Figure 2G ).

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