Novel tumor suppressor microRNA at frequently deleted chromosomal region 8p21 regulates epidermal growth factor receptor in prostate cancer.

Considering the association of chr8p21 loss with poor prognosis, our findings are highly significant and support a novel concept that associates a long standing observation of frequent loss of a chromosomal region with a novel miRNA in prostate cancer.

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This trend suggests that miR-3622b expression is progressively downregulated in tumors with higher Gleason grade and stage though this correlation failed to reach statistical significance.

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