Correlation of each factor to the Profilin-1 levels per individual sample did not reach statistical significance for Wnt5b, PLCb4, ANGPT1 with the exception of CREB1 which suprisingly showed a strong inverse correlation (p=0.005; ρ=-0.943, Spearman's Rho) to the PFN1 levels in the pT2 + samples.
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Silencing of Profilin-1 suppresses cell adhesion and tumor growth via predicted alterations in integrin and Ca2+ signaling in T24M-based bladder cancer models.
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