RG7112 significantly suppressed the growth of xenografted RMG-I cells ( P = 0.033 by t-test, Figure 4A-4C ) and tended to suppress the growth of the OVISE cells, although the growth suppression in OVISE cells did not reach statistical significance ( P = 0.061, Supplementary Figure 6A ).
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MDM2 is a potential therapeutic target and prognostic factor for ovarian clear cell carcinomas with wild type TP53.
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