Methylation of RAD51B, XRCC3 and other homologous recombination genes is associated with expression of immune checkpoints and an inflammatory signature in squamous cell carcinoma of the head and neck, lung and cervix.

Genes involved in homologous recombination and nucleotide excision repair pathways made up the highest absolute (n=8) number of genes in lung squamous cell carcinoma but did not reach statistical significance for relative enrichment also when only the 22 genes with statistical significance were considered (p=0.36).

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