A combined gene expression and functional study reveals the crosstalk between N-Myc and differentiation-inducing microRNAs in neuroblastoma cells.

As shown in Figure 5E–5F , combined siMYCN and miR-506-3p mimic treatment shows enhanced expression of differentiation markers and reduced cell viability comparing to either MYCN knockdown or miR-506-3p in all the four cell lines, although the decrease of cell viability by combined siMYCN and miR-506-3p mimic treatment relative to miR-506-3p treatment alone did not reach statistical significance in SKNFI cells.

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