TRIB2 confers resistance to anti-cancer therapy by activating the serine/threonine protein kinase AKT.

Nat Commun · 2017 · PMC5347136 · PMID 28276427

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a strong trendno p-value reported

For pancreatic cancer, there was only a strong trend for high- TRIB2 expression, primarily due to the extremely poor overall prognosis exhibited in pancreatic cancer patients.

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highly significantno p-value reported

Furthermore, survival data from the GSE65904 dataset revealed a highly significant TRIB2 -dependent distant metastasis-free survival time or disease-specific survival time response ( Fig. 4g,h ).

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