With this “days 0, 2, 4, 7” schedule there was significant amplification of the combinatorial therapeutic effect over the tTF-NGR single drug treatment and a clear trend for better therapeutic outcome of the combination when compared with doxorubicin given alone.
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Combinatorial effects of doxorubicin and retargeted tissue factor by intratumoral entrapment of doxorubicin and proapoptotic increase of tumor vascular infarction.
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