Systematic errors in detecting biased agonism: Analysis of current methods and development of a new model-free approach.

Sci Rep · 2017 · PMC5349545 · PMID 28290478

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of marginal significanceno p-value reported

5 ), which indicates that possible biased efficacies possessed by such compounds must be of marginal significance.

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highly significantno p-value reported

7 (bottom panel) the 11 agonists exhibited highly significant deviations from the reference trajectory consistent with strong efficacy bias towards arrestin, and confirm that the method is fully competent in detecting the presence of biased efficacy in ligands.

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