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CCL2 nitration is a negative regulator of chemokine-mediated inflammation.

Sci Rep · 2017 · PMC5349559 · PMID 28290520

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Although this difference did not reach statistical significance, the trend suggests that nitration reduced the affinity of CCL2 for CCR2 around 6-fold.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.