Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells.

ACS Chem Biol · 2016 · PMC5349656 · PMID 27779865

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Cell survival in Shh-Light2 cells is independent of the Hh pathway; however, cell viability measurements showed a trend of substantial Shh-Light2 cytotoxicity for RUSKI-41 and RUSKI-43 (EC 50 = 21 ± 1.4 μM and 11 ± 2.5 μM, respectively), whereas RUSKI-201 had no effect on cell viability at concentrations >25 μM ( Supporting Information Figure S2 ).

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