4β-Hydroxycholesterol Level in Patients With Rheumatoid Arthritis Before vs. After Initiation of bDMARDs and Correlation With Inflammatory State.

In fact, switching from a statistically significant to a highly significant correlation between 4 β OHC level and CRP before vs. after initiation of therapy clearly indicates that bDMARD treatment in our study mainly reduced cytokines not suppressing CYP3A4 phenotype.

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When plotting the individual baseline 4 β OHC levels against the respective paired after:before 4 β OHC ratios, a negative trend between the two variables was apparent (i.e., those with lowest baseline obtained highest ratios and vice versa; Figure 1 c ).

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