Furthermore, mice after receiving 2 weeks of pretreatment with high-dose paeoniflorin, the percentage of sucrose consumption was increased compared with the saline-treated group and the escitalopram group, although this failed to reach statistical significance (one-way ANOVA, F 5,43 =1.69, P >0.05.
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Paeoniflorin ameliorates interferon-alpha-induced neuroinflammation and depressive-like behaviors in mice.
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Furthermore, although the astrocyte density did not significantly change in the amygdala, there was an increasing trend.