Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis.

brucei with quarfloxin, which was highly significant (*** P = <0.001) in all cases.

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Data was considered ‘significant’ where P = 0.01-0.05 (*), ‘very significant’ where P = 0.001-0.01 (**) or ‘extremely significant’ where P = <0.001 (***).

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Our experiments using Pol I inhibitors show that these two types of Pol I transcription complexes at either the rDNA or the active ES are inhibited in a similar fashion, although there are clearly significant differences in their control.

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