Of the remaining 8 genes, the differential expression of 4 genes, DPP4 , BCAT1 , CNTNAP4 and CDH3 , each showed a trend towards predicting worse survival, and in combination, this 4-gene set correlated with earlier onset of metastatic disease compared with cases without expression changes in these genes (Figure 7A, p =0.0667).
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Src promotes castration-recurrent prostate cancer through androgen receptor-dependent canonical and non-canonical transcriptional signatures.
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