Opposing roles of PIK3CA gene alterations to EZH2 signaling in non-muscle invasive bladder cancer.

By immunoblotting, we observed that the presence of PIK3CA mutations or PTEN gene LOH were associated with increased Akt Ser 473 and Thr 308 phosphorylation., We also observed that these cells also showed a trend to display partial reduction of EZH2 and increased Ser 21 phosphorylated EZH2 levels (Figure 4A ).

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We found a highly significant overlap between the downregulated genes characteristic of recurrent tumors with those upregulated in tumors with PIK3CA gene alterations (Figure 1B ).

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