Dual SYK/JAK inhibition overcomes ibrutinib resistance in chronic lymphocytic leukemia: Cerdulatinib, but not ibrutinib, induces apoptosis of tumor cells protected by the microenvironment.

Although there was a trend for ZAP70 positive cases to be more sensitive to cerdulatinib, the difference between the ZAP70 positive or negative subgroups did not reach statistical significance ( Supplementary Figure 1C ).

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