A study found that patients with MDD that responded to mirtazapine or SSRI treatment had higher baseline saliva MHPG concentrations, although this did not reach statistical significance in patients receiving mirtazapine alone, or when it was used as adjunctive therapy with SSRIs ( 47 ).
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The Role of Norepinephrine and Its α-Adrenergic Receptors in the Pathophysiology and Treatment of Major Depressive Disorder and Schizophrenia: A Systematic Review.
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