Extracellular Hsp90 and TGFβ regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model.

BMC Cancer · 2017 · PMC5356307 · PMID 28302086

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a clear trendno p-value reported

The most intriguing finding in this study was that a combination of TGF-β1, Hsp90β and the TGF-βRI inhibitor SB431542 markedly decreased the level of adhesion, while increasing migration and AIG of both SW480 and SW620 cells, revealing a clear trend towards metastatic behaviour of the cells in response to this combination of treatments.

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