Genetic inhibition of autophagy promotes p53 loss-of-heterozygosity and tumorigenesis.

Oncotarget · 2016 · PMC5356529 · PMID 27655644

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did not reach statistical significanceno p-value reported

Expression of Atg5 K130R in a tp53 M214K/M214K background caused slightly earlier and higher tumor incidence compared to tp53 M214K/M214K homozygotes (60% incidence: median age of onset 16 months), but the difference did not reach statistical significance (Figure 2 ).

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