Effects of prophylactic ibuprofen and paracetamol administration on the immunogenicity and reactogenicity of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugated vaccine (PHiD-CV) co-administered with DTPa-combined vaccines in children: An open-label, randomized, controlled, non-inferiority trial.

Effect of ibuprofen on co-administered antigens Post-primary vaccination, a borderline significant difference in antibody GMCs was observed in the IIBU vs NIBU comparison for FHA (UL = 0.99), in the DIBU vs NIBU comparison for tetanus (UL = 1.00) and in the IIBU vs NIBU comparison for hepatitis B surface antigen (HBs) (UL = 1.01) ( Table 3 ).

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Prophylactic administration of paracetamol during primary series showed a trend for reduced post-primary anti-pneumococcal antibody GMCs when given immediately after vaccine administration (for the majority of vaccine serotypes) or when given in a delayed manner (for some serotypes).

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