Barely Significant
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Notable Increasing Trend in Azole Non-susceptible <i>Candida tropicalis</i> Causing Invasive Candidiasis in China (August 2009 to July 2014): Molecular Epidemiology and Clinical Azole Consumption.

Front Microbiol · 2017 · PMC5360734 · PMID 28382028

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a significant trendno p-value reported
Conclusion Our findings show an unusual high-level of fluconazole and voriconazole resistance, and a significant trend of increasing azole non-susceptibility among C. tropicalis isolates from IC in China for the period August 2009 to July 2014, which is particularly notable during the last 2 years.

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