Interestingly, 4-HNE treatment caused a significant increase in cell number (p<0.05), a trend that was also seen in cells treated with metformin and insulin but did not reach statistical significance (p=0.06) ( Fig. 3 E). 4 Discussion The intra-abdominal OM adipose tissue has unique anatomic and metabolic characteristics compared to adipose tissues at other locations [36] .
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Combined metformin and insulin treatment reverses metabolically impaired omental adipogenesis and accumulation of 4-hydroxynonenal in obese diabetic patients.
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