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The lack of the organic cation transporter OCT1 at the plasma membrane of tumor cells precludes a positive response to sorafenib in patients with hepatocellular carcinoma.

Oncotarget · 2017 · PMC5362528 · PMID 28178663

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The effect of positive OCT1 staining at the plasma membrane on radiological response was less pronounced and did not reach statistical significance (Figure 7A ).

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