Metabolic Response of Visceral White Adipose Tissue of Obese Mice Exposed for 5 Days to Human Room Temperature Compared to Mouse Thermoneutrality.

Key genes of M1 macrophage inflammation, such as S100 calcium binding protein A8 ( S100a8 ), and chemokine (C-C motif) ligand 8 ( Ccl8 ) were significantly down regulated or showed a trend toward a down regulation in the 22°C housed mice, while M2 macrophage genes were not differentially regulated (Figure 4B ).

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