Effective Depletion of Pre-existing Anti-AAV Antibodies Requires Broad Immune Targeting.

Importantly, in side-by-side comparisons, functional analyses of bone marrow Ab-secreting cells using the enzyme-linked immunospot (ELISpot) method also showed reduced frequencies of IgG-secreting cells in Rap + Pred-treated mice ( Figures 3 A and 3B), and a trend also was evident when assessing AAV9-specific IgG-secreting cells ( Figure 3 C), though the difference did not reach statistical significance.

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