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Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension.

Circulation · 2017 · PMC5363837 · PMID 28137936

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A trend toward increased heart rate for both peptides did not reach statistical significance ( online-only Data Supplement Figure VII ).

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