A functional variant in NEPH3 gene confers high risk of renal failure in primary hematuric glomerulopathies. Evidence for predisposition to microalbuminuria in the general population.

PLoS One · 2017 · PMC5363870 · PMID 28334007

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0000

boldest claim

The sentences

highly significantp = 1.3x10 -5actually significant

Two further general population cohorts, KORAF4 and SAPHIR confirmed the association, and a meta-analysis of all three cohorts (11,258 individuals) was highly significant (p = 1.3x10 -5 , OR = 7.46).

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did not reach statistical significanceno p-value reported

P-PERK did not reach statistical significance despite the obvious trend observed in cells transfected with the mutant 353M allele.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.