The soft mechanical signature of glial scars in the central nervous system.

However, the lower but still clearly significant decrease in cortical tissue stiffness at greater distances from the injury site (that is, 500–1,000 μm, corresponding to regions A′, C′ and D′ in Fig. 2 ), particularly in those regions containing myelinated fibres of the cingulum (regions medial to the scar, Fig. 3 and Supplementary Table 4 ), was mostly accompanied by an upregulation of glial intermediate filaments ( Fig. 5b, c and Supplementary Fig. 4b, c ).

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