Can we use gonadotropin plasma concentration as surrogate marker for BMI-related incomplete estrogen suppression in breast cancer patients receiving anastrozole?

BMC Cancer · 2017 · PMC5371265 · PMID 28351392

Europe PMC DOI

hedged sentences

0.0550

closest p · 1.1× alpha

0.0880

boldest claim

The sentences

a trend that approached significancep = 0.055so close (0.05 < p ≤ 0.1)

failed to reach statistical significanceno p-value reported

However, after controlling for age in the model for FSH, BMI failed to reach statistical significance but stayed in the model showing a trend that approached significance ( p = 0.055).

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a trend towards significancep = 0.088so close (0.05 < p ≤ 0.1)

Finally, analysis revealed a trend towards significance for the association of estradiol with FSH ( r = −0.147, p = 0.088) and SHBG ( r = 0.-165, p = 0.063) but not for LH ( r = 0.00, p = 0.990).

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