Corticosteroids in septic shock: a systematic review and network meta-analysis.

First, they were given as immunosuppressants; large doses of glucocorticoids that have significant immune effects such as dexamethasone and methylprednisolone were given until studies in the late 1980s [ 23 – 27 ] showed a trend towards increased rates of superinfection and these high dose studies were halted.

also in 53,322 other papers

Thus, although at an individual level the included patients are ‘jointly randomisable’, between the groups there are likely to be significant differences.

also in 1,824 other papers