HPV16 and 18 genome amplification show different E4-dependence, with 16E4 enhancing E1 nuclear accumulation and replicative efficiency via its cell cycle arrest and kinase activation functions.

PLoS Pathog · 2017 · PMC5371391 · PMID 28306742

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difference was apparentno p-value reported

However, no significant and/or reproducible difference was apparent between WT and E4KO genomes of either HPV16 or 18.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.