Dexmedetomidine's inhibitory effects on acetylcholine release from cholinergic nerves in guinea pig trachea: a mechanism that accounts for its clinical benefit during airway irritation.

The exogenouse acetylcholine-induced contractile muscle force was 52.3% after 1000 μM lidocaine, but after statistical adjustment for multiple concentration points, this failed to reach statistical significance (103 ± 3.69 vs 50.7 ± 13.6%; p = 0.03).

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