Screening for AMPA receptor auxiliary subunit specific modulators.

In addition, VU0539491 showed PAM activity in the A2Q-GSG cell line ( Fig 9C green trace), which appeared as a positive trend in the CRC calculated from GLUslope ( Fig 9D A2Q-GSG) and was corroborated by a more robust fit in the CRC calculated from the AUC ( Fig 9E A2Q-GSG).

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In fact, the CRCs calculated from GLUslope did not show a negative trend on any cell line except A2Q-stg ( Fig 7D ).

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