highly significantp < 5e-04
6 ) and PLS-DA model validation by permutation tests was highly significant (p < 5e-04).
6 ) and PLS-DA model validation by permutation tests was highly significant (p < 5e-04).
Results Cohort 1: Time to event curves for 5-year mortality showed a trend to statistically lower probability of death within 5 years in patients with PCSK9 LOF (overall p = 0.062) and the presence of 1 PCSK9 LOF allele (Cox model) was independently associated with decreased hazard-ratio for 5-year mortality (0.578, 95% CI = 0.36-0.93, p = 0.024).