PROX1 gene CC genotype as a major determinant of early onset of type 2 diabetes in slavic study participants from Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation study.

2 a, the highly significant earlier age of onset of T2D observed in individuals of Slavic origin was also present among the 175 Slavic study participants living in countries of predominantly Celtic populations, suggesting a genetic drive for this trait.

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Associations that are nominally significant in each of the two independent Celtic and Slavic GWAS and that increase in significance in the combined Celtic and Slavic GWAS are considered to be replicated in two independent subcohorts, that is, Celtic and Slavic genetic profile populations.

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