Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses.

Consistently with the decreased pDC type I IFN induction, systemic type I IFN bioactivity and IFN-α protein levels appeared reduced in Lyn −/− and Fyn −/− MCMV-infected mice versus their WT counterparts, although differences did not reach statistical significance for the Lyn −/− group ( Fig. 3c ).

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