Immunodeficiency in advanced cancer has been well documented and there is a significant trend of decreasing functional T cell populations (including CD4, CD8, CD4:CD8 ratio and naïve T cells) with cancer progression: this is associated with increased morbidity and mortality [ 56 ].
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A systematically structured review of biomarkers of dying in cancer patients in the last months of life; An exploration of the biology of dying.
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