Sensitivity of the UK Clinical Practice Research Datalink to Detect Neurodevelopmental Effects of Medicine Exposure in Utero: Comparative Analysis of an Antiepileptic Drug-Exposed Cohort.

In the CPRD, the prevalence of NDDs was increased amongst offspring antenatally exposed to carbamazepine, valproate (monotherapy and polytherapy) and non-valproate polytherapy combinations when compared with offspring born to women without epilepsy, but these increases did not reach statistical significance (Table 2 ).

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The exposure window sensitivity analysis did not alter these findings, although the ‘monotherapy other’ category did reduce to borderline significance.

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