A Pooled Analysis of Clinical Pharmacology Trials Investigating the Pharmacokinetic and Pharmacodynamic Characteristics of Fast-Acting Insulin Aspart in Adults with Type 1 Diabetes.

In subjects with type 2 diabetes, a more heterogeneous population than subjects with type 1 diabetes, superiority of faster aspart over IAsp could not be confirmed for the reduction from baseline in 2-h postprandial glucose increment as the difference in favour of faster aspart did not reach statistical significance (−0.36 mmol/L [−0.81 to 0.08]; −6.6 mg/dL [−14.5 to 1.4]; p = non-significant), while the reduction from baseline in 1-h postprandial glucose increment was statistically significantly greater for faster aspart than for IAsp (−0.59 mmol/L [−1.09 to −0.09]; −10.6 mg/dL [−19.6 to −1.7]; p = 0.0198) [ 18 ].

also in 111,027 other papers