In agreement with our previous study, 16 Ganet alone suppressed the growth of p53Q/− lymphomas to a greater extent than that of p53−/− lymphomas ( Supplementary Figures 1a and b , gray versus yellow lines; Figures 1b and c ), although this did not reach statistical significance (data not shown).
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Ganetespib synergizes with cyclophosphamide to improve survival of mice with autochthonous tumors in a mutant p53-dependent manner.
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