Long-Term Safety of PEGylated Coagulation Factor VIII in the Immune-Deficient Rowett Nude Rat.

For the 26-week study, at weeks 13 and 26, there was a dose-related shortening of mean aPTT at all doses in males, although the shortening did not reach statistical significance in Group Two males (50 IU/kg) in week 26 ( Table 5 ).

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